Efficacy of Soiled Bedding Transfer for Transmission of Mouse and Rat Infections to Sentinels: A Systematic Review.

ABSTRACT:

Purpose

This systematic review was conducted to gain insight into the efficacy of transmission of infectious agents to colony sentinels by soiled bedding transfer based on publications studying this subject in mice and rats. This information is essential to establish recommendations for the design of health monitoring programs which use sentinels to determine the microbiological status of laboratory animal colonies.

Results

Fifteen original articles retrieved from PubMed, Embase, and CAB abstracts met the inclusion criteria. The design of the studies varied substantially per infectious agent with regard to dose of soiled bedding, exposure time, and sentinel strains used.

Conclusion

With our conservative criteria for effectiveness, soiled bedding transfer appeared to b

SUBMITTER: de Bruin WC 

PROVIDER: S-EPMC4982683 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature