Genetic and Sex-Specific Transgenerational Effects of a High Fat Diet in Drosophila melanogaster.

ABSTRACT: An organism's phenotype is the product of its environment and genotype, but an ancestor's environment can also be a contributing factor. The recent increase in caloric intake and decrease in physical activity of developed nations' populations is contributing to deteriorating health and making the study of the longer term impacts of a changing lifestyle a priority. The dietary habits of ancestors have been shown to affect phenotype in several organisms, including humans, mice, and the fruit fly. Whether the ancestral dietary effect is purely environmental or if there is a genetic interaction with the environment passed down for multiple generations, has not been determined previously. Here we used the fruit fly, Drosophila melanogaster, to investigate the genetic, sex-specific, and environm

SUBMITTER: Dew-Budd K 

PROVIDER: S-EPMC4982694 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature