PET imaging of prostate-specific membrane antigen in prostate cancer: current state of the art and future challenges.

ABSTRACT:

Background

Prostate-specific membrane antigen (PSMA) is a cell surface enzyme that is highly expressed in prostate cancer (PCa) and is currently being extensively explored as a promising target for molecular imaging in a variety of clinical contexts. Novel antibody and small-molecule PSMA radiotracers labeled with a variety of radionuclides for positron emission tomography (PET) imaging applications have been developed and explored in recent studies.

Methods

A great deal of progress has been made in defining the clinical utility of this class of PET agents through predominantly small and retrospective clinical studies. The most compelling data to date has been in the setting of biochemically recurrent PCa, where PSMA-targeted radiotracers have been found to be superior to co

SUBMITTER: Rowe SP 

PROVIDER: S-EPMC4982789 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature