RETRACTED: Protonation State-Dependent Communication in Cytochrome c Oxidase.

ABSTRACT: Proton transfer in cytochrome c oxidase from the cellular inside to the binuclear redox center (BNC) can occur through two distinct pathways, the D- and K-channels. For the protein to function as both redox enzyme and proton pump, proton transfer out of either of the channels toward the BNC or into the protein toward a proton loading site, and ultimately through the membrane, must be highly regulated. The O→E intermediate of cytochrome c oxidase is the first redox state in its catalytic cycle, where proton transfer through the K-channel, from K362 to Y288 at the BNC, is important. Molecular dynamics simulations of this intermediate with 16 different combinations of protonation states of key residues in the D- and K-channel show the mutual impact of the two proton-conducting channels to be

SUBMITTER: Helabad MB 

PROVIDER: S-EPMC4982942 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature