Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma.

ABSTRACT:

Background

Pancreatic cancer is poorly characterized at genetic and non-genetic levels. The current study evaluates in a large cohort of patients the prognostic relevance of molecular subtypes and key transcription factors in pancreatic ductal adenocarcinoma (PDAC).

Methods

We performed gene expression analysis of whole-tumor tissue obtained from 118 surgically resected PDAC and 13 histologically normal pancreatic tissue samples. Cox regression models were used to study the effect on survival of molecular subtypes and 16 clinicopathological prognostic factors. In order to better understand the biology of PDAC we used iRegulon to identify transcription factors (TFs) as master regulators of PDAC and its subtypes.

Results

We confirmed the PDAssign gene signature as class

SUBMITTER: Janky R 

PROVIDER: S-EPMC4983037 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature