ITAR: a web server for identifying target genes of transcription factors using ChIP-seq or ChIP-chip data.

ABSTRACT:

Background

Chromatin immunoprecipitation followed by massively parallel DNA sequencing (ChIP-seq) or microarray hybridization (ChIP-chip) has been widely used to determine the genomic occupation of transcription factors (TFs). We have previously developed a probabilistic method, called TIP (Target Identification from Profiles), to identify TF target genes using ChIP-seq/ChIP-chip data. To achieve high specificity, TIP applies a conservative method to estimate significance of target genes, with the trade-off being a relatively low sensitivity of target gene identification compared to other methods. Additionally, TIP's output does not render binding-peak locations or intensity, information highly useful for visualization and general experimental biological use, while the variability

SUBMITTER: Yang CC 

PROVIDER: S-EPMC4983039 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature