Ontology highlight
ABSTRACT:
SUBMITTER: Zhang XD
PROVIDER: S-EPMC4983190 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Cancer cell 20160428 5
Proteasome inhibitors have revolutionized outcomes in multiple myeloma, but they are used empirically, and primary and secondary resistance are emerging problems. We have identified TJP1 as a determinant of plasma cell proteasome inhibitor susceptibility. TJP1 suppressed expression of the catalytically active immunoproteasome subunits LMP7 and LMP2, decreased proteasome activity, and enhanced proteasome inhibitor sensitivity in vitro and in vivo. This occurred through TJP1-mediated suppression o ...[more]