Levels of folate receptor autoantibodies in maternal and cord blood and risk of neural tube defects in a Chinese population.

ABSTRACT:

Background

After years of periconceptional folic acid supplementation, the prevalence of neural tube defects (NTDs) remains stable following the remarkable reduction observed immediately after the fortification practice. There is accumulating evidence that folate receptor (FR) autoimmunity may play a role in the etiology of folate-sensitive NTDs.

Methods

From 2011 to 2013, 118 NTD cases and 242 healthy controls were recruited from a population-based birth defects surveillance system in Northern China. Enzyme-linked immunosorbent assay was used to measure FR autoantibodies in maternal and cord blood. Logistic regression models were used to estimate the odds ratios (OR) and 95% confidence intervals (95% CI).

Results

Plasma FR autoantibodies levels were significantly ele

SUBMITTER: Yang N 

PROVIDER: S-EPMC4983204 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature