ABO blood group associations with markers of endothelial dysfunction in the Multi-Ethnic Study of Atherosclerosis.

ABSTRACT:

Background and aims

ABO blood type is associated with cardiovascular disease, although the underlying mechanisms are presumed to be complex. While the relationship between non-O blood types and von Willebrand Factor (vWF) is well-established, associations with cellular adhesion molecules (CAMs) across diverse populations are understudied.

Methods

We genetically inferred ABO alleles for N = 6202 participants from the Multi-Ethnic Study of Atherosclerosis. Linear regression was used to evaluate associations between major ABO allele dosages and log-transformed measurements of vWF (N = 924), soluble E-selectin (sE-selectin, N = 925), soluble P-selectin (sP-selectin, N = 2392), and soluble ICAM-1 (sICAM-1, N = 2236) by race/ethnicity.

Results

For the selectins, the A1 alle

SUBMITTER: Larson NB 

PROVIDER: S-EPMC4983247 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature