Pathway analysis in attention deficit hyperactivity disorder: An ensemble approach.

ABSTRACT: Despite a wealth of evidence for the role of genetics in attention deficit hyperactivity disorder (ADHD), specific and definitive genetic mechanisms have not been identified. Pathway analyses, a subset of gene-set analyses, extend the knowledge gained from genome-wide association studies (GWAS) by providing functional context for genetic associations. However, there are numerous methods for association testing of gene sets and no real consensus regarding the best approach. The present study applied six pathway analysis methods to identify pathways associated with ADHD in two GWAS datasets from the Psychiatric Genomics Consortium. Methods that utilize genotypes to model pathway-level effects identified more replicable pathway associations than methods using summary statistics. In addition,

SUBMITTER: Mooney MA 

PROVIDER: S-EPMC4983253 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature