Coupled Sensing of Hunger and Thirst Signals Balances Sugar and Water Consumption.

ABSTRACT: Hunger and thirst are ancient homeostatic drives for food and water consumption. Although molecular and neural mechanisms underlying these drives are currently being uncovered, less is known about how hunger and thirst interact. Here, we use molecular genetic, behavioral, and anatomical studies in Drosophila to identify four neurons that modulate food and water consumption. Activation of these neurons promotes sugar consumption and restricts water consumption, whereas inactivation promotes water consumption and restricts sugar consumption. By calcium imaging studies, we show that these neurons are directly regulated by a hormone signal of nutrient levels and by osmolality. Finally, we identify a hormone receptor and an osmolality-sensitive ion channel that underlie this regulation. Thus, a

SUBMITTER: Jourjine N 

PROVIDER: S-EPMC4983267 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature