PET Evidence of the Effect of Donepezil on Cognitive Performance in an Animal Model of Chemobrain.

ABSTRACT: A considerable number of patients with breast cancer complain of cognitive impairment after chemotherapy. In this study, we showed that donepezil enhanced memory function and increased brain glucose metabolism in a rat model of cognitive impairment after chemotherapy using behavioral analysis and positron emission tomography (PET). We found that chemotherapy affected spatial learning ability, reference memory, and working memory and that donepezil improved these cognitive impairments. According to PET analysis, chemotherapy reduced glucose metabolism in the medial prefrontal cortex and hippocampus, and donepezil increased glucose metabolism in the bilateral frontal lobe, parietal lobe, and hippocampus. Reduced glucose metabolism was more prominent after treatment with doxorubicin than cycl

SUBMITTER: Lim I 

PROVIDER: S-EPMC4983340 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature