Development of a tiered and binned genetic counseling model for informed consent in the era of multiplex testing for cancer susceptibility.

ABSTRACT:

Purpose

Multiplex genetic testing, including both moderate- and high-penetrance genes for cancer susceptibility, is associated with greater uncertainty than traditional testing, presenting challenges to informed consent and genetic counseling. We sought to develop a new model for informed consent and genetic counseling for four ongoing studies.

Methods

Drawing from professional guidelines, literature, conceptual frameworks, and clinical experience, a multidisciplinary group developed a tiered-binned genetic counseling approach proposed to facilitate informed consent and improve outcomes of cancer susceptibility multiplex testing.

Results

In this model, tier 1 "indispensable" information is presented to all patients. More specific tier 2 information is provided to supp

SUBMITTER: Bradbury AR 

PROVIDER: S-EPMC4983405 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature