A delta-opioid receptor genetic variant is associated with abstinence prior to and during cocaine dependence treatment.

ABSTRACT:

Introduction

An intronic polymorphism in the delta-opioid receptor gene (OPRD1) was previously associated with cocaine dependence in African-Americans. However, it is not known if the polymorphism (rs678849) is associated with dependence-related phenotypes within the cocaine dependent population.

Methods

Cocaine and alcohol dependent subjects were randomized to either topiramate or placebo. Abstinence from cocaine use was confirmed by urine drug screens for benzoylecgonine three times per week. Cocaine withdrawal and craving were assessed at randomization using the Cocaine Selective Severity Assessment (CSSA) and Minnesota Cocaine Craving Scale (MCCS), respectively. Subjects were also interviewed using the Addiction Severity Index (ASI). Genotype at rs678849 was determined f

SUBMITTER: Crist RC 

PROVIDER: S-EPMC4983478 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature