Biomedical Mutation Analysis (BMA): A software tool for analyzing mutations associated with antiviral resistance.

ABSTRACT:

Introduction

Hepatitis C virus (HCV) is considered a major public health problem, with 200 million people infected worldwide. The treatment for HCV chronic infection with pegylated interferon alpha plus ribavirin inhibitors is unspecific; consequently, the treatment is effective in only 50% of patients infected. This has prompted the development of direct-acting antivirals (DAA) that target virus proteins. These DAA have demonstrated a potent effect in vitro and in vivo; however, virus mutations associated with the development of resistance have been described.

Objective

To design and develop an online information system for detecting mutations in amino acids known to be implicated in resistance to DAA.

Materials and methods

   We have used computer applications, tech

SUBMITTER: Salvatierra K 

PROVIDER: S-EPMC4984484 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature