Assessment of clinical findings, tryptase levels, and bone marrow histopathology in the management of pediatric mastocytosis.

ABSTRACT: BACKGROUND:The management of children with pediatric mastocytosis poses a challenge. This is because there is limited information as to the application of clinical and laboratory findings and bone marrow histopathology as they relate to medical intervention and communication. OBJECTIVE:We sought to examine clinical aspects of pediatric mastocytosis in relationship to serum tryptase levels and bone marrow pathology to provide practical guidance for management. METHODS:Between 1986 and 2012, 105 children were evaluated at the National Institutes of Health. Organomegaly was confirmed by means of ultrasound. Baseline tryptase levels and at least 1 subsequent tryptase measurement was available in 84 and 37 of these children, respectively. Fifty-three children underwent a bone marrow examination

SUBMITTER: Carter MC 

PROVIDER: S-EPMC4984538 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature