Genomic events underlying the changes in adamantane resistance among influenza A(H3N2) viruses during 2006-2008.

ABSTRACT:

Background

Adamantanes resistance in H3N2 viruses has been increasing since 2000, and in 2005-2006 reached nearly 100% in most countries, with the circulation of the N-lineage. In 2006-2007, however, a significant decrease in resistance was observed in many regions.

Objectives

To explore potential links between adamantane resistance and the A(H3N2) viruses that circulated between 2006 and 2008.

Methods

A total of 1451 Influenza A (H3N2) viruses collected globally in 2001-2008 were screened for the presence of adamantane resistance markers. A subset of 100 viruses representing the broad genetic and geographic spectrum of these viruses was selected for complete genome sequencing and phylogenetic analyses.

Results

Full genome sequence analysis of 2006-2007 viruses

SUBMITTER: Deyde V 

PROVIDER: S-EPMC4984730 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature