MYC functions are specific in biological subtypes of breast cancer and confers resistance to endocrine therapy in luminal tumours.

ABSTRACT:

Background

MYC is amplified in approximately 15% of breast cancers (BCs) and is associated with poor outcome. c-MYC protein is multi-faceted and participates in many aspects of cellular function and is linked with therapeutic response in BCs. We hypothesised that the functional role of c-MYC differs between molecular subtypes of BCs.

Methods

We therefore investigated the correlation between c-MYC protein expression and other proteins involved in different cellular functions together with clinicopathological parameters, patients' outcome and treatments in a large early-stage molecularly characterised series of primary invasive BCs (n=1106) using immunohistochemistry. The METABRIC BC cohort (n=1980) was evaluated for MYC mRNA expression and a systems biology approach utilised

SUBMITTER: Green AR 

PROVIDER: S-EPMC4984797 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature