Pre-diagnostic circulating sex hormone levels and risk of prostate cancer by ERG tumour protein expression.

ABSTRACT:

Background

Experimental studies have shown androgen receptor stimulation to facilitate formation of the TMPRSS2:ERG gene fusion in prostate cell lines. No study has tested whether higher pre-diagnostic circulating sex hormone levels in men increase risk of developing TMPRSS2:ERG-positive prostate cancer specifically.

Methods

We conducted a nested case-control study of 200 prostate cancer cases and 1057 controls from the Physicians' Health Study and Health Professionals Follow-up Study. We examined associations between pre-diagnostic circulating levels of total testosterone, free testosterone, DHT, androstanediol glucuronide, estradiol, and SHBG and risk of prostate cancer by TMPRSS2:ERG status. TMPRSS2:ERG was estimated by ERG immunohistochemistry. We used multivariable unco

SUBMITTER: Graff RE 

PROVIDER: S-EPMC4984801 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature