Antitumour activity of the novel flavonoid Oncamex in preclinical breast cancer models.

ABSTRACT:

Background

The natural polyphenol myricetin induces cell cycle arrest and apoptosis in preclinical cancer models. We hypothesised that myricetin-derived flavonoids with enhanced redox properties, improved cell uptake and mitochondrial targeting might have increased potential as antitumour agents.

Methods

We studied the effect of a second-generation flavonoid analogue Oncamex in a panel of seven breast cancer cell lines, applying western blotting, gene expression analysis, fluorescence microscopy and immunohistochemistry of xenograft tissue to investigate its mechanism of action.

Results

Proliferation assays showed that Oncamex treatment for 8 h reduced cell viability and induced cytotoxicity and apoptosis, concomitant with increased caspase activation. Microarray anal

SUBMITTER: Martinez-Perez C 

PROVIDER: S-EPMC4984802 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature