Long-term impact of liver function on curative therapy for hepatocellular carcinoma: application of the ALBI grade.

ABSTRACT:

Background

Application of curative therapy for hepatocellular carcinoma is crucially dependent on underlying liver function. Using the recently described ALBI grade we examined the long-term impact of liver dysfunction on survival of early-stage hepatocellular carcinoma (HCC) patients.

Methods

This cohort study comprised 2559 HCC patients from different geographic regions, all treated with curative intent. We also examined the relation between indocyanine green (ICG) clearance and ALBI score. Survival was measured from the date of treatment to the date of death or last follow-up.

Results

The ALBI score correlated well with ICG clearance. Among those undergoing surgical resection, patients with ALBI grade-1 (good liver function) survived approximately twice as long as

SUBMITTER: Toyoda H 

PROVIDER: S-EPMC4984858 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature