From obesity to diabetes and cancer: epidemiological links and role of therapies.

ABSTRACT: Increasing evidence suggests a complex relationship between obesity, diabetes and cancer. Here we review the evidence for the association between obesity and diabetes and a wide range of cancer types. In many cases the evidence for a positive association is strong, but for other cancer types a more complex picture emerges with some site-specific cancers associated with obesity but not to diabetes, and some associated with type I but not type II diabetes. The evidence therefore suggests the existence of cumulative common and differential mechanisms influencing the relationship between these diseases. Importantly, we highlight the influence of antidiabetics on cancer and antineoplastic agents on diabetes and in particular that antineoplastic targeting of insulin/IGF-1 signalling induces hype

SUBMITTER: Garcia-Jimenez C 

PROVIDER: S-EPMC4984860 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature