The effect of aspirin and nonsteroidal anti-inflammatory drug use after diagnosis on survival of oesophageal cancer patients.

ABSTRACT:

Background

Aspirin use has been shown to lower incidence and mortality in cancer patients. The aim of this population-based study was to determine the effect of postdiagnosis low-dose aspirin use on survival of patients with oesophageal cancer.

Methods

Patients with oesophageal cancer (1998-2010) were selected from the Eindhoven Cancer Registry and linked with outpatient pharmacy data regarding aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs). Users were subdivided into both prediagnosis and postdiagnosis or only postdiagnosis users. Parametric survival models with an exponential (Poisson) distribution were used with non-specific death as endpoint.

Results

In this study 560 patients were included. Overall, 157 patients (28.0%) were non-users, 293 patients (52

SUBMITTER: van Staalduinen J 

PROVIDER: S-EPMC4984910 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature