Soluble tumour necrosis factor receptor type II and survival in colorectal cancer.

ABSTRACT:

Background

Chronic inflammation may play a role in colorectal cancer (CRC) pathogenesis. The relationship between soluble tumour necrosis factor receptor type II (sTNF-RII) and survival among CRC patients is not well defined.

Methods

We prospectively evaluated the association between pre-diagnosis plasma levels of sTNF-RII and mortality in 544 CRC patients from the Nurses' Health Study and Health Professionals Follow-Up Study diagnosed from 1990 to 2010. Primary and secondary end points were overall and CRC-specific mortality, respectively. Cox proportional hazards models were used to calculate multivariate hazard ratios for mortality.

Results

Higher sTNF-RII levels were significantly associated with increased overall mortality (multivariate HR=1.48, 95% CI 1.02-2.16,

SUBMITTER: Babic A 

PROVIDER: S-EPMC4984918 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature