Synchronous Multiple Lung Adenocarcinomas: Estrogen Concentration in Peripheral Lung.

ABSTRACT:

Background

The detection rate of synchronous multiple lung adenocarcinomas (SMLA), which display multiple ground glass opacity nodules in the peripheral lung, is increasing due to advances in high resolution computed tomography. The backgrounds of multicentric development of adenocarcinoma are unknown. In this study, we quantitated estrogen concentration in the peripheral lungs of postmenopausal female patients with SMLA.

Methods

The tissue concentration of estrogens (estrone [E1] and estdadiol [E2]) in the noncancerous peripheral lung were measured with liquid chromatography/electrospray tandem mass spectrometry in postmenopausal female patients with lung adenocarcinoma. The expression levels of CYP19A1 in the normal lung were also quantitated with real-time PCR. Thirty pat

SUBMITTER: Ikeda K 

PROVIDER: S-EPMC4985140 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature