A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome.

ABSTRACT: Low-grade chronic inflammation is a key etiological phenomenon responsible for the initiation and perpetuation of obesity and diabetes. Novel therapeutic approaches that can specifically target inflammatory pathways are needed to avert this looming epidemic of metabolic disorders. Genetic and chemical inhibition of SH2-containing inositol 5' phosphatase 1 (SHIP1) has been associated with systemic expansion of immunoregulatory cells that promote a lean-body state; however, SHIP1 function in immunometabolism has never been assessed. This led us to investigate the role of SHIP1 in metabolic disorders during excess caloric intake in mice. Using a small-molecule inhibitor of SHIP1 (SHIPi), here we show that SHIPi treatment in mice significantly reduces body weight and fat content, improves cont

SUBMITTER: Srivastava N 

PROVIDER: S-EPMC4985248 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature