Ontology highlight
ABSTRACT:
SUBMITTER: Wu NC
PROVIDER: S-EPMC4985287 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
eLife 20160708
The structure of fitness landscapes is critical for understanding adaptive protein evolution. Previous empirical studies on fitness landscapes were confined to either the neighborhood around the wild type sequence, involving mostly single and double mutants, or a combinatorially complete subgraph involving only two amino acids at each site. In reality, the dimensionality of protein sequence space is higher (20(L)) and there may be higher-order interactions among more than two sites. Here we expe ...[more]