Does Once-Daily Raltegravir Have Any Role in the Antiretroviral Treatment?

ABSTRACT: Administering raltegravir once daily would make adherence to antiretroviral treatment easier, especially if the concomitant drugs are also administered once daily. We report our experience on the use of raltegravir, both once- and twice-daily.Retrospective review of HIV-infected patients on treatment with raltegravir 800 mg once or 400 mg twice a day plus 2 analogs. Patients were classified as group A (subjects switched to raltegravir due to adverse events on a previous regimen or drug-drug interactions) and group B (subjects who restarted antiretroviral treatment after a previous drop-out). The primary clinical endpoint was the percentage of subjects with virological suppression after 96 weeks. Treatment's effectiveness (noncomplete/missing equals failure) was also evaluated. Pharmacokine

SUBMITTER: Gutierrez-Valencia A 

PROVIDER: S-EPMC4985381 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature