A novel KLF6-Rho GTPase axis regulates hepatocellular carcinoma cell migration and dissemination.

ABSTRACT: The presence of invasion into the extra-hepatic portion of the portal vein or the development of distant metastases renders hepatocellular carcinoma (HCC) patients ineligible for the only potential curative options for this malignancy-tumor resection or organ transplantation. Gene expression profiling of murine HCC cell lines identified KLF6 as a potential regulator of HCC cell migration. KLF6 knockdown increases cell migration, consistent with the correlation between decreased KLF6 mRNA levels and the presence of vascular invasion in human HCC. Concordantly, single-copy deletion of Klf6 in a HCC mouse model results in increased tumor formation, increased metastasis to the lungs and decreased survival, indicating that KLF6 suppresses both HCC development and metastasis. By combining gene e

SUBMITTER: Ahronian LG 

PROVIDER: S-EPMC4985511 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature