Chronic disease outcomes after severe acute malnutrition in Malawian children (ChroSAM): a cohort study.

ABSTRACT:

Background

Tackling severe acute malnutrition (SAM) is a global health priority. Heightened risk of non-communicable diseases (NCD) in children exposed to SAM at around 2 years of age is plausible in view of previously described consequences of other early nutritional insults. By applying developmental origins of health and disease (DOHaD) theory to this group, we aimed to explore the long-term effects of SAM.

Methods

We followed up 352 Malawian children (median age 9·3 years) who were still alive following SAM inpatient treatment between July 12, 2006, and March 7, 2007, (median age 24 months) and compared them with 217 sibling controls and 184 age-and-sex matched community controls. Our outcomes of interest were anthropometry, body composition, lung function, physical capa

SUBMITTER: Lelijveld N 

PROVIDER: S-EPMC4985564 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature