Gut microbiota associated with HIV infection is significantly enriched in bacteria tolerant to oxygen.

ABSTRACT:

Objectives

Gut microbiota modifications occurring during HIV infection have recently been associated with inflammation and microbial translocation. However, discrepancies between studies justified a comprehensive analysis performed on a large sample size.

Design and methods

In a case-control study, next-generation sequencing of the 16S rRNA gene was applied to the faecal microbiota of 31 HIV-infected patients, of whom 18 were treated with antiretroviral treatment (ART), compared with 27 healthy controls. 21 sera samples from HIV-infected patients and 7 sera samples from control participants were used to test the presence of 25 markers of inflammation and/or immune activation.

Results

Diversity was significantly reduced in HIV individuals when compared with controls an

SUBMITTER: Dubourg G 

PROVIDER: S-EPMC4985784 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature