Study of seven single-nucleotide polymorphisms identified in East Asians for association with obesity in a Taiwanese population.

ABSTRACT:

Objective

This study aimed to examine single-nucleotide polymorphisms (SNPs) of seven previously reported obesity genes in East Asians and to analyse their associations and synergistic effects on obesity in the Taiwanese population.

Design

Cross-sectional study.

Setting

One medical centre in northern Taiwan.

Participants

A total of 323 non-obese and 264 obese participants were recruited. The threshold for obesity in this study was a body mass index of ≥27 kg/m(2), as defined by the Ministry of Health and Welfare in Taiwan. The study was performed with the approval of the institutional review board of MacKay Memorial Hospital, Taipei, Taiwan (application number 12MMHIS106).

Outcome measures

We analysed the genotype distributions of seven SNPs localising t

SUBMITTER: Huang WH 

PROVIDER: S-EPMC4986083 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature