Diversity and frequency of kdr mutations within Anopheles sinensis populations from Guangxi, China.

ABSTRACT:

Background

Anopheles sinensis is a major vector of malaria in China and its control is under great threat as the development of insecticide resistance. Voltage-gated sodium channel (VGSC) is the target of several classes of insecticides. Genetic mutations of VGSC have been documented to confer knockdown resistance (kdr) to dichlorodiphenyltrichloroethane (DDT) and pyrethroids in mosquitoes. To control this vector efficiently, it is important to know the resistance-associated genetic mutations, their distribution frequencies and genealogical relations.

Methods

Three hundreds and thirteen (313) adults of An. sinensis collected from nine locations across Guangxi Zhuang Autonomous Region were used. The partial sequence of the An. sinensis voltage gated sodium channel gene (AS-VG

SUBMITTER: Yang C 

PROVIDER: S-EPMC4986192 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature