Salivary peptidome profiling for diagnosis of severe early childhood caries.

ABSTRACT:

Background

Severe early childhood caries (s-ECC), which has quite high prevalence among children, is a widespread problem with significant impacts among both developing and developed countries. At present, it is widely known that no early detective techniques and diagnostic tests could have high sensitivity and specificity when using for clinical screening of s-ECC. In this study, we had applied magnetic bead (MB)-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) to screen distinctive candidate biomarkers of this disease, so as to establish protein profiles and diagnostic models of s-ECC.

Methods

Firstly, we used the technique mentioned above to detect specifically expressed peptides in saliva samples from ten children with s-E

SUBMITTER: Sun X 

PROVIDER: S-EPMC4986381 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature