Mucosal antibody responses are directed by viral burden in children with acute influenza infection.

ABSTRACT:

Background

Influenza infection causes excess hospitalizations and deaths in younger patients, but susceptibility to severe disease is poorly understood. While mucosal antibodies can limit influenza-associated infection and disease, little is known about acute mucosal antibody responses to influenza infection.

Objectives

These studies characterize mucosal antiviral antibody production in children during lower respiratory infection (LRI) with H1N1 influenza versus other viral LRI and examine the relationship between mucosal antiviral antibodies and protection against severe disease.

Methods

B lymphocytes were assessed by immunohistochemistry in lung tissue from infants with fatal acute seasonal influenza infection. Nasopharyngeal secretions (NPS) were obtained at presen

SUBMITTER: He Y 

PROVIDER: S-EPMC4986624 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature