DOT1L-mediated H3K79me2 modification critically regulates gene expression during cardiomyocyte differentiation.

ABSTRACT: Epigenetic changes on DNA and chromatin are implicated in cell differentiation and organogenesis. For the heart, distinct histone methylation profiles were recently linked to stage-specific gene expression programs during cardiac differentiation in vitro. However, the enzymes catalyzing these modifications and the genes regulated by them remain poorly defined. We therefore decided to identify the epigenetic enzymes that are potentially involved in cardiomyogenesis by analyzing the expression profile of the 85 genes encoding the epigenetic-related proteins in mouse cardiomyocytes (CMs), and then study how they affect gene expression during differentiation and maturation of this cell type. We show here with gene expression screening of epigenetic enzymes that the highly expressed H3 methyltr

SUBMITTER: Cattaneo P 

PROVIDER: S-EPMC4986629 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature