Y-Chromosome Structural Diversity in the Bonobo and Chimpanzee Lineages.

ABSTRACT: The male-specific regions of primate Y-chromosomes (MSY) are enriched for multi-copy genes highly expressed in the testis. These genes are located in large repetitive sequences arranged as palindromes, inverted-, and tandem repeats termed amplicons. In humans, these genes have critical roles in male fertility and are essential for the production of sperm. The structure of human and chimpanzee amplicon sequences show remarkable difference relative to the remainder of the genome, a difference that may be the result of intense selective pressure on male fertility. Four subspecies of common chimpanzees have undergone extended periods of isolation and appear to be in the early process of subspeciation. A recent study found amplicons enriched for testis-expressed genes on the primate X-chromosom

SUBMITTER: Oetjens MT 

PROVIDER: S-EPMC4987114 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature