The Genomic Landscape of Male Breast Cancers.

ABSTRACT:

Purpose

Male breast cancer is rare, and its genomic landscape has yet to be fully characterized. Lacking studies in men, treatment of males with breast cancer is extrapolated from results in females with breast cancer. We sought to define whether male breast cancers harbor somatic genetic alterations in genes frequently altered in female breast cancers.

Experimental design

All male breast cancers were estrogen receptor-positive, and all but two were HER2-negative. Fifty-nine male breast cancers were subtyped by immunohistochemistry, and tumor-normal pairs were microdissected and subjected to massively parallel sequencing targeting all exons of 241 genes frequently mutated in female breast cancers or DNA-repair related. The repertoires of somatic mutations and copy number alt

SUBMITTER: Piscuoglio S 

PROVIDER: S-EPMC4987160 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature