CITED2 Modulates Breast Cancer Metastatic Ability through Effects on IKKα.

ABSTRACT:

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Previously, we identified the transcriptional coactivator CITED2 as a potential facilitator of bone metastasis using a murine mammary cancer model. Extending these studies to human breast cancer, it was observed that CITED2 mRNA expression was significantly elevated in patient specimens of metastatic breast cancer relative to primary tumors, with highest levels in metastasis to bone relative to non-bone sites. To further evaluate CITED2 functions in breast cancer metastasis, CITED2 expression was stably reduced in the human breast cancer cell lines MDA-MB-231 and MDA-MB-468, which are metastatic in animal models. While CITED2 knockdown had no effect on cell proliferation, cell migration and invasion were significantly reduced, as was the establishment of metastasis follo

SUBMITTER: Jayaraman S 

PROVIDER: S-EPMC4987170 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature