Inhibition of Intestinal Thiamin Transport in Rat Model of Sepsis.

ABSTRACT:

Objectives

Thiamin deficiency is highly prevalent in patients with sepsis, but the mechanism by which sepsis induces thiamin deficiency is unknown. This study aimed to determine the influence of various severity of sepsis on carrier-mediated intestinal thiamin uptake, level of expressions of thiamin transporters (thiamin transporter-1 and thiamin transporter-2), and mitochondrial thiamin pyrophosphate transporter.

Design

Randomized controlled study.

Setting

Research laboratory at a Veterans Affairs Medical Center.

Subjects

Twenty-four Sprague-Dawley rats were randomized into controls, mild, moderate, and severe sepsis with equal number of animals in each group.

Interventions

Sepsis was induced by cecal ligation and puncture with the cecum ligated below t

SUBMITTER: Sassoon CS 

PROVIDER: S-EPMC4987227 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature