Altered Stress-Induced Regulation of Genes in Monocytes in Adults with a History of Childhood Adversity.

ABSTRACT: Exposure to serious or traumatic events early in life can lead to persistent alterations in physiological stress response systems, including enhanced cross talk between the neuroendocrine and immune system. These programming effects may be mechanistically involved in mediating the effects of adverse childhood experience on disease risk in adulthood. We investigated hormonal and genome-wide mRNA expression responses in monocytes to acute stress exposure, in a sample of healthy adults (n=30) with a history of early childhood adversity, and a control group (n=30) without trauma experience. The early adversity group showed altered hypothalamus-pituitary-adrenal axis responses to stress, evidenced by lower ACTH and cortisol responses. Analyses of gene expression patterns showed that stress-resp

SUBMITTER: Schwaiger M 

PROVIDER: S-EPMC4987852 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature