GAM: a web-service for integrated transcriptional and metabolic network analysis.

ABSTRACT: Novel techniques for high-throughput steady-state metabolomic profiling yield information about changes of nearly thousands of metabolites. Such metabolomic profiles, when analyzed together with transcriptional profiles, can reveal novel insights about underlying biological processes. While a number of conceptual approaches have been developed for data integration, easily accessible tools for integrated analysis of mammalian steady-state metabolomic and transcriptional data are lacking. Here we present GAM ('genes and metabolites'): a web-service for integrated network analysis of transcriptional and steady-state metabolomic data focused on identification of the most changing metabolic subnetworks between two conditions of interest. In the web-service, we have pre-assembled metabolic netwo

SUBMITTER: Sergushichev AA 

PROVIDER: S-EPMC4987878 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature