Protein Frustratometer 2: a tool to localize energetic frustration in protein molecules, now with electrostatics.

ABSTRACT: The protein frustratometer is an energy landscape theory-inspired algorithm that aims at localizing and quantifying the energetic frustration present in protein molecules. Frustration is a useful concept for analyzing proteins' biological behavior. It compares the energy distributions of the native state with respect to structural decoys. The network of minimally frustrated interactions encompasses the folding core of the molecule. Sites of high local frustration often correlate with functional regions such as binding sites and regions involved in allosteric transitions. We present here an upgraded version of a webserver that measures local frustration. The new implementation that allows the inclusion of electrostatic energy terms, important to the interactions with nucleic acids, is signi

SUBMITTER: Parra RG 

PROVIDER: S-EPMC4987889 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature