Genonets server-a web server for the construction, analysis and visualization of genotype networks.

ABSTRACT: A genotype network is a graph in which vertices represent genotypes that have the same phenotype. Edges connect vertices if their corresponding genotypes differ in a single small mutation. Genotype networks are used to study the organization of genotype spaces. They have shed light on the relationship between robustness and evolvability in biological systems as different as RNA macromolecules and transcriptional regulatory circuits. Despite the importance of genotype networks, no tool exists for their automatic construction, analysis and visualization. Here we fill this gap by presenting the Genonets Server, a tool that provides the following features: (i) the construction of genotype networks for categorical and univariate phenotypes from DNA, RNA, amino acid or binary sequences; (ii) ana

SUBMITTER: Khalid F 

PROVIDER: S-EPMC4987894 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature