InterEvDock: a docking server to predict the structure of protein-protein interactions using evolutionary information.

ABSTRACT: The structural modeling of protein-protein interactions is key in understanding how cell machineries cross-talk with each other. Molecular docking simulations provide efficient means to explore how two unbound protein structures interact. InterEvDock is a server for protein docking based on a free rigid-body docking strategy. A systematic rigid-body docking search is performed using the FRODOCK program and the resulting models are re-scored with InterEvScore and SOAP-PP statistical potentials. The InterEvScore potential was specifically designed to integrate co-evolutionary information in the docking process. InterEvDock server is thus particularly well suited in case homologous sequences are available for both binding partners. The server returns 10 structures of the most likely consensus

SUBMITTER: Yu J 

PROVIDER: S-EPMC4987904 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature