NAPS: Network Analysis of Protein Structures.

ABSTRACT: Traditionally, protein structures have been analysed by the secondary structure architecture and fold arrangement. An alternative approach that has shown promise is modelling proteins as a network of non-covalent interactions between amino acid residues. The network representation of proteins provide a systems approach to topological analysis of complex three-dimensional structures irrespective of secondary structure and fold type and provide insights into structure-function relationship. We have developed a web server for network based analysis of protein structures, NAPS, that facilitates quantitative and qualitative (visual) analysis of residue-residue interactions in: single chains, protein complex, modelled protein structures and trajectories (e.g. from molecular dynamics simulations)

SUBMITTER: Chakrabarty B 

PROVIDER: S-EPMC4987928 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature