ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules.

ABSTRACT: The degree of evolutionary conservation of an amino acid in a protein or a nucleic acid in DNA/RNA reflects a balance between its natural tendency to mutate and the overall need to retain the structural integrity and function of the macromolecule. The ConSurf web server (http://consurf.tau.ac.il), established over 15 years ago, analyses the evolutionary pattern of the amino/nucleic acids of the macromolecule to reveal regions that are important for structure and/or function. Starting from a query sequence or structure, the server automatically collects homologues, infers their multiple sequence alignment and reconstructs a phylogenetic tree that reflects their evolutionary relations. These data are then used, within a probabilistic framework, to estimate the evolutionary rates of each sequ

SUBMITTER: Ashkenazy H 

PROVIDER: S-EPMC4987940 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature