Antiviral Activity of Myticin C Peptide from Mussel: an Ancient Defense against Herpesviruses.

ABSTRACT:

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Little is known about the antiviral response in mollusks. As in other invertebrates, the interferon signaling pathways have not been identified, and in fact, there is a debate about whether invertebrates possess antiviral immunity similar to that of vertebrates. In marine bivalves, due to their filtering activity, interaction with putative pathogens, including viruses, is very high, suggesting that they should have mechanisms to address these infections. In this study, we confirmed that constitutively expressed molecules in naive mussels confer resistance in oysters to ostreid herpesvirus 1 (OsHV-1) when oyster hemocytes are incubated with mussel hemolymph. Using a proteomic approach, myticin C peptides were identified in both mussel hemolymph and hemocytes. Myticins, an

SUBMITTER: Novoa B 

PROVIDER: S-EPMC4988142 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature