Phasins, Multifaceted Polyhydroxyalkanoate Granule-Associated Proteins.

ABSTRACT: Phasins are the major polyhydroxyalkanoate (PHA) granule-associated proteins. They promote bacterial growth and PHA synthesis and affect the number, size, and distribution of the granules. These proteins can be classified in 4 families with distinctive characteristics. Low-resolution structural studies and in silico predictions were performed in order to elucidate the structure of different phasins. Most of these proteins share some common structural features, such as a preponderant α-helix composition, the presence of disordered regions that provide flexibility to the protein, and coiled-coil interacting regions that form oligomerization domains. Due to their amphiphilic nature, these proteins play an important structural function, forming an interphase between the hydrophobic content of

SUBMITTER: Mezzina MP 

PROVIDER: S-EPMC4988190 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature