Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study.

ABSTRACT:

Background

The patterns of regional metastasis in adenoid cystic carcinoma (ACC) of the head and neck and its association with outcome is not established.

Methods

We conducted a retrospective multicentered multivariate analysis of 270 patients who underwent neck dissection.

Results

The incidence rate of neck metastases was 29%. The rate observed in the oral cavity is 37%, and in the major salivary glands is 19% (p = .001). The rate of occult nodal metastases was 17%. Overall 5-year survival rates were 44% in patients undergoing therapeutic neck dissections, and 65% and 73% among those undergoing elective neck dissections, with and without nodal metastases, respectively (p = .017). Multivariate analysis revealed that the primary site, nodal classification, and margin s

SUBMITTER: Amit M 

PROVIDER: S-EPMC4988229 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature